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  THE NELSON LAB
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Structural Chemistry

Chemoenzymatic Synthesis of (+)-Xyloketal B
Romero, E. O.; Perkins, J. C.; Burch, J. E.; Delgadillo, D. A.; Nelson, H. M.; Narayan, A. R. H. Org. Lett. 2023, In Press.
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Sterically Invariant Carborane-Based Ligands for the Morphological and Electronic Control of Metal–Organic Chalcogenolate Assemblies 
Mills, H. A.; Jones, C. G.; Anderson, K. P.; Ready, A. D.; Djurovich, P. I.; Khan, S. I.; Hohman, N. J.; Nelson, H. M.; Spokoyny, A. M. Chem. Mat. ​2022, 15, 6933–6943.
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Conductive Stimuli-Responsive Coordination Network Linked with Bismuth for Chemiresistive Gas Sensing 
Aykanat, A.; Jones, C. G.; Cline, E.; Stolz, R. M.; Meng, Z.; Nelson, H. M.; Mirica, K. A. ACS Appl. Mater. Interfaces 2021, 50, 60306–60318.
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Solution-processable and functionalizable ultra-high molecular weight polymers via topochemical synthesis 
Anderson, C. L.; Li, H.; Jones, C. G.; Teat, S. J.; Settineri, N. S.; Dailing, E. A.; Liang, J.; Mao, H.; Klivansky, L. M.; Li, X.; Reimer, J. A.; Nelson, H. M.; Liu, Y. Nat. Commun. 2021, 12, 1–8. ​
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Unraveling the Electrical and Magnetic Properties of Lawyered Conductive Metal− Organic Framework With Atomic Precision 
Meng, Z.; Jones, C. G.; Farid, S.; Khan, I. U.; Nelson, H. M.; Mirica, K. A. Angew. Chem. Int. Ed. 2021, 60, ​2–11. 
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Putting MicroED to the Test: An Account of the Evaluation of 30 Diverse Pharmaceutical Compounds 
Burch, J. E.; Smith, A. G.; Caille, Seb.; Walker, S. D.; Wurz, R.; Cee, V. J.; Rodriguez, J.; Gostovic, D.; Quasdorf, K.; Nelson, H. M. ChemRxiv 2021.
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Biosynthesis of the Fusarium Mycotoxin (–)-Sambutoxin 
Go, E. B.; Kim, L. J.; Nelson, H. M.; Ohashi, M.; Tang, Y. Org. Lett. 2021, 23, 7819–7823.
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Prospecting for natural products by genome mining and microcystal electron diffraction 
Kim, L. J.; Ohashi, M.; Tan, D.; Asay, M.; Cascio, D.; Rodriguez, J; Tang, Y.; Nelson, H. M. Nat. Chem. Bio. 2021, 17, 872–877. 
This article was highlighted in C&EN.
First appeared on ChemRxiv.
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Enhanced Gearing Fidelity Achieved Through Macrocyclization of a Solvated Molecular Spur Gear 
Jellen, M. J.; Liepuoniute, I.; Jin, M.; Jones, C. G.; Yang, S.; Jiang, X.; Nelson, H. M.;  Houk, K. N.; Garcia-Garibay, M. A. J. Am. Chem. Soc. 2021, 143, 7740–7747.
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Structural Revision of the Lomaiviticins 
Kim, L. J.; Xue, M.; Li, X.; Xu, Z.; Paulson, E.; Mercado, B. Q.; Nelson, H. M.; Herzon, S. J. Am. Chem. Soc. 2021, 143, 6578–6585.
This article was highlighted in C&EN.
First appeared on ChemRxiv.
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Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO-N3 Charge-Transfer Complex 
Nelson, H. M.; Siu, J. C.; Saha, A.; Cascio, D.; MacMillan, S. N.; Wu, S. B.; Lu, C.; Rodriguez, J. A.; Houk, K. N.; Lin, S. Org. Lett. 2021, 2, 454–458.
First appeared on ChemRxiv.
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Elucidation of Diverse Solid-State Packing in a Family of Electron-Deficient Expanded Helicenes via Microcrystal Electron Diffraction (MicroED) 
Samkian, A.; Kiel, G. R.; Jones, C. G.; Bergman, H.; Oktawiec, J.; Nelson, H. M.; Tilley, T. D. Angew. Chem. Int. Ed. 2020, 5, 2493–2499. 
First appeared on ChemRxiv.
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Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in Caenorhabditis elegans by Combining Synthesis and MicroED 
Curtis, B. J.; Kim, L. J.; Wrobel, C. J. J.; Eagen, J. M.; Smith, R. A.; Burch, J. E.; Le, H. H.; Artyukhin, A. B.; Nelson, H. M.; Schroeder, F. C. Org. Lett. 2020, 22, 6724–6728.
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Characterization of Reactive Organometallic Species via MicroED 
Jones, C. G.; Asay, M.; Kim, L. J.; Kleinsasser, J. F.; Saha, A.; Fulton, T. J.; Berkly, K. R.; Cascio, D.; Malyutin, A. G.; Conley, M. P.; Stoltz, B. M.; Lavallo, V.; Rodriguez, J. A.; Nelson, H. M. ACS Cent. Sci. 2019, 5, 1507–1513.
First appeared on ChemRxiv.
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The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination 
Jones, C. G.; Martynowycz, M. W.; Hattne, J.; Fulton, T. J.; Stoltz, B. M.; Rodriguez, J. A.; Nelson, H. M.; Gonen, T. ACS Cent. Sci. 2018, 4, 1587–1592. 
First appeared on ChemRxiv.
This article was highlighted in ScienceNews, Science In the Pipeline, Nature & C&EN, NIH Director's Blog.
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