Genome Mining from Agriculturally Relevant Fungi Led to a D-Glucose Esterified Polyketide with a Terpene-like Core Structure
Yan, C.; Han, W.; Zhou, Q.; Niwa, K.; Tang, M. J.; Burch, J. E.; Zhang, Y.; Delgadillo, D. A.; Sun, Z.; Wu, Z.; Jacobsen, S. E.; Nelson, H. M.; Houk, K. N.; Tang, Y. J. Am. Chem. Soc. 2023, in press.
Yan, C.; Han, W.; Zhou, Q.; Niwa, K.; Tang, M. J.; Burch, J. E.; Zhang, Y.; Delgadillo, D. A.; Sun, Z.; Wu, Z.; Jacobsen, S. E.; Nelson, H. M.; Houk, K. N.; Tang, Y. J. Am. Chem. Soc. 2023, in press.
A Heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway
Lin, S. Y.; Oakley, C. E.; Jenkinson, C. B.; Chiang, Y. M.; Lee, C. K.; Jones, C. G.; Seidler, P. M.; Nelson, H. M.; Todd, R. B.; Wang, C.C.; Oakley, B.R. Chem. Sci. 2023, 14, 11022–11032.
Lin, S. Y.; Oakley, C. E.; Jenkinson, C. B.; Chiang, Y. M.; Lee, C. K.; Jones, C. G.; Seidler, P. M.; Nelson, H. M.; Todd, R. B.; Wang, C.C.; Oakley, B.R. Chem. Sci. 2023, 14, 11022–11032.
High-throughput Identification of Crystalline Natural Products from Crude Extracts Enabled by Microarray Technology and MicroED
Delgadillo, D. A.; Burch, J. E.; Kim, L. J.; de Moraes L.; Niwa, K.; Williams, J.; Tang, M. J.; Lavallo, V.; Chhetri, B.; Jones, C. G.; Rodriguez, I. H.; Signore, J.; Marquez, L.; Bhanushali, R.; Greene, M.; Woo, S.; Kubanek, J.; Quave, C. L.; Tang, Y.; Nelson, H. M. ChemRxiv 2023.
Delgadillo, D. A.; Burch, J. E.; Kim, L. J.; de Moraes L.; Niwa, K.; Williams, J.; Tang, M. J.; Lavallo, V.; Chhetri, B.; Jones, C. G.; Rodriguez, I. H.; Signore, J.; Marquez, L.; Bhanushali, R.; Greene, M.; Woo, S.; Kubanek, J.; Quave, C. L.; Tang, Y.; Nelson, H. M. ChemRxiv 2023.
Cryptic Chemical Variation in a Marine Red Alga as Revealed by Nontargeted Metabolomics
Chhetri, B. K.; Mojib, N.; Moore, S. G.; Delgadillo, D. A.; Burch, J. E.; Barrett, N. H.; Gaul, D. A.; Marquez, L.; Soapi, K.; Nelson, H. M.; Quave, C. L.; Kubanek, J. ACS Omega 2023, 8, 15, 13899–13910.
Chhetri, B. K.; Mojib, N.; Moore, S. G.; Delgadillo, D. A.; Burch, J. E.; Barrett, N. H.; Gaul, D. A.; Marquez, L.; Soapi, K.; Nelson, H. M.; Quave, C. L.; Kubanek, J. ACS Omega 2023, 8, 15, 13899–13910.
Chemoenzymatic Synthesis of (+)-Xyloketal B
Romero, E. O.; Perkins, J. C.; Burch, J. E.; Delgadillo, D. A.; Nelson, H. M.; Narayan, A. R. H. Org. Lett. 2023, 25, 9, 1547–1552.
Romero, E. O.; Perkins, J. C.; Burch, J. E.; Delgadillo, D. A.; Nelson, H. M.; Narayan, A. R. H. Org. Lett. 2023, 25, 9, 1547–1552.
Sterically Invariant Carborane-Based Ligands for the Morphological and Electronic Control of Metal–Organic Chalcogenolate Assemblies
Mills, H. A.; Jones, C. G.; Anderson, K. P.; Ready, A. D.; Djurovich, P. I.; Khan, S. I.; Hohman, N. J.; Nelson, H. M.; Spokoyny, A. M. Chem. Mat. 2022, 15, 6933–6943.
Mills, H. A.; Jones, C. G.; Anderson, K. P.; Ready, A. D.; Djurovich, P. I.; Khan, S. I.; Hohman, N. J.; Nelson, H. M.; Spokoyny, A. M. Chem. Mat. 2022, 15, 6933–6943.
Conductive Stimuli-Responsive Coordination Network Linked with Bismuth for Chemiresistive Gas Sensing
Aykanat, A.; Jones, C. G.; Cline, E.; Stolz, R. M.; Meng, Z.; Nelson, H. M.; Mirica, K. A. ACS Appl. Mater. Interfaces 2021, 50, 60306–60318.
Aykanat, A.; Jones, C. G.; Cline, E.; Stolz, R. M.; Meng, Z.; Nelson, H. M.; Mirica, K. A. ACS Appl. Mater. Interfaces 2021, 50, 60306–60318.
Solution-processable and functionalizable ultra-high molecular weight polymers via topochemical synthesis
Anderson, C. L.; Li, H.; Jones, C. G.; Teat, S. J.; Settineri, N. S.; Dailing, E. A.; Liang, J.; Mao, H.; Klivansky, L. M.; Li, X.; Reimer, J. A.; Nelson, H. M.; Liu, Y. Nat. Commun. 2021, 12, 1–8.
Anderson, C. L.; Li, H.; Jones, C. G.; Teat, S. J.; Settineri, N. S.; Dailing, E. A.; Liang, J.; Mao, H.; Klivansky, L. M.; Li, X.; Reimer, J. A.; Nelson, H. M.; Liu, Y. Nat. Commun. 2021, 12, 1–8.
Unraveling the Electrical and Magnetic Properties of Lawyered Conductive Metal− Organic Framework With Atomic Precision
Meng, Z.; Jones, C. G.; Farid, S.; Khan, I. U.; Nelson, H. M.; Mirica, K. A. Angew. Chem. Int. Ed. 2021, 60, 2–11.
Meng, Z.; Jones, C. G.; Farid, S.; Khan, I. U.; Nelson, H. M.; Mirica, K. A. Angew. Chem. Int. Ed. 2021, 60, 2–11.
Putting MicroED to the Test: An Account of the Evaluation of 30 Diverse Pharmaceutical Compounds
Burch, J. E.; Smith, A. G.; Caille, Seb.; Walker, S. D.; Wurz, R.; Cee, V. J.; Rodriguez, J.; Gostovic, D.; Quasdorf, K.; Nelson, H. M. ChemRxiv 2021.
Burch, J. E.; Smith, A. G.; Caille, Seb.; Walker, S. D.; Wurz, R.; Cee, V. J.; Rodriguez, J.; Gostovic, D.; Quasdorf, K.; Nelson, H. M. ChemRxiv 2021.
Biosynthesis of the Fusarium Mycotoxin (–)-Sambutoxin
Go, E. B.; Kim, L. J.; Nelson, H. M.; Ohashi, M.; Tang, Y. Org. Lett. 2021, 23, 7819–7823.
Go, E. B.; Kim, L. J.; Nelson, H. M.; Ohashi, M.; Tang, Y. Org. Lett. 2021, 23, 7819–7823.
Prospecting for natural products by genome mining and microcystal electron diffraction
Kim, L. J.; Ohashi, M.; Tan, D.; Asay, M.; Cascio, D.; Rodriguez, J; Tang, Y.; Nelson, H. M. Nat. Chem. Bio. 2021, 17, 872–877.
This article was highlighted in C&EN.
First appeared on ChemRxiv.
Kim, L. J.; Ohashi, M.; Tan, D.; Asay, M.; Cascio, D.; Rodriguez, J; Tang, Y.; Nelson, H. M. Nat. Chem. Bio. 2021, 17, 872–877.
This article was highlighted in C&EN.
First appeared on ChemRxiv.
Enhanced Gearing Fidelity Achieved Through Macrocyclization of a Solvated Molecular Spur Gear
Jellen, M. J.; Liepuoniute, I.; Jin, M.; Jones, C. G.; Yang, S.; Jiang, X.; Nelson, H. M.; Houk, K. N.; Garcia-Garibay, M. A. J. Am. Chem. Soc. 2021, 143, 7740–7747.
Jellen, M. J.; Liepuoniute, I.; Jin, M.; Jones, C. G.; Yang, S.; Jiang, X.; Nelson, H. M.; Houk, K. N.; Garcia-Garibay, M. A. J. Am. Chem. Soc. 2021, 143, 7740–7747.
Structural Revision of the Lomaiviticins
Kim, L. J.; Xue, M.; Li, X.; Xu, Z.; Paulson, E.; Mercado, B. Q.; Nelson, H. M.; Herzon, S. J. Am. Chem. Soc. 2021, 143, 6578–6585.
This article was highlighted in C&EN.
First appeared on ChemRxiv.
Kim, L. J.; Xue, M.; Li, X.; Xu, Z.; Paulson, E.; Mercado, B. Q.; Nelson, H. M.; Herzon, S. J. Am. Chem. Soc. 2021, 143, 6578–6585.
This article was highlighted in C&EN.
First appeared on ChemRxiv.
Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO-N3 Charge-Transfer Complex
Nelson, H. M.; Siu, J. C.; Saha, A.; Cascio, D.; MacMillan, S. N.; Wu, S. B.; Lu, C.; Rodriguez, J. A.; Houk, K. N.; Lin, S. Org. Lett. 2021, 2, 454–458.
First appeared on ChemRxiv.
Nelson, H. M.; Siu, J. C.; Saha, A.; Cascio, D.; MacMillan, S. N.; Wu, S. B.; Lu, C.; Rodriguez, J. A.; Houk, K. N.; Lin, S. Org. Lett. 2021, 2, 454–458.
First appeared on ChemRxiv.
Elucidation of Diverse Solid-State Packing in a Family of Electron-Deficient Expanded Helicenes via Microcrystal Electron Diffraction (MicroED)
Samkian, A.; Kiel, G. R.; Jones, C. G.; Bergman, H.; Oktawiec, J.; Nelson, H. M.; Tilley, T. D. Angew. Chem. Int. Ed. 2020, 5, 2493–2499.
First appeared on ChemRxiv.
Samkian, A.; Kiel, G. R.; Jones, C. G.; Bergman, H.; Oktawiec, J.; Nelson, H. M.; Tilley, T. D. Angew. Chem. Int. Ed. 2020, 5, 2493–2499.
First appeared on ChemRxiv.
Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in Caenorhabditis elegans by Combining Synthesis and MicroED
Curtis, B. J.; Kim, L. J.; Wrobel, C. J. J.; Eagen, J. M.; Smith, R. A.; Burch, J. E.; Le, H. H.; Artyukhin, A. B.; Nelson, H. M.; Schroeder, F. C. Org. Lett. 2020, 22, 6724–6728.
Curtis, B. J.; Kim, L. J.; Wrobel, C. J. J.; Eagen, J. M.; Smith, R. A.; Burch, J. E.; Le, H. H.; Artyukhin, A. B.; Nelson, H. M.; Schroeder, F. C. Org. Lett. 2020, 22, 6724–6728.
Characterization of Reactive Organometallic Species via MicroED
Jones, C. G.; Asay, M.; Kim, L. J.; Kleinsasser, J. F.; Saha, A.; Fulton, T. J.; Berkly, K. R.; Cascio, D.; Malyutin, A. G.; Conley, M. P.; Stoltz, B. M.; Lavallo, V.; Rodriguez, J. A.; Nelson, H. M. ACS Cent. Sci. 2019, 5, 1507–1513.
First appeared on ChemRxiv.
Jones, C. G.; Asay, M.; Kim, L. J.; Kleinsasser, J. F.; Saha, A.; Fulton, T. J.; Berkly, K. R.; Cascio, D.; Malyutin, A. G.; Conley, M. P.; Stoltz, B. M.; Lavallo, V.; Rodriguez, J. A.; Nelson, H. M. ACS Cent. Sci. 2019, 5, 1507–1513.
First appeared on ChemRxiv.
The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination
Jones, C. G.; Martynowycz, M. W.; Hattne, J.; Fulton, T. J.; Stoltz, B. M.; Rodriguez, J. A.; Nelson, H. M.; Gonen, T. ACS Cent. Sci. 2018, 4, 1587–1592.
First appeared on ChemRxiv.
This article was highlighted in ScienceNews, Science In the Pipeline, Nature & C&EN, NIH Director's Blog.
Jones, C. G.; Martynowycz, M. W.; Hattne, J.; Fulton, T. J.; Stoltz, B. M.; Rodriguez, J. A.; Nelson, H. M.; Gonen, T. ACS Cent. Sci. 2018, 4, 1587–1592.
First appeared on ChemRxiv.
This article was highlighted in ScienceNews, Science In the Pipeline, Nature & C&EN, NIH Director's Blog.
